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GLP-1s, or GLP-1 receptor agonists, are medications that mimic the action of the naturally occurring hormone glucagon-like peptide-1 and occupy its receptors

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Each class offers distinct advantages, with progression from single to dual to triple agonism showing incrementally greater weight loss and metabolic improvements

p = 0.0003, number needed to treat = 20, 95% CI 14 to 40)